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White papers

TCR sequencing for cancer vaccine development

To know the efficacy of your cancer vaccine, it is crucial to analyse the T cell response. Because of its versatility, TCR sequencing is a rising tool to monitor such immune responses. However, the full potential of TCR sequencing remains unrealised at present.

This white paper is directed toward researchers and developers of therapeutic cancer vaccines. It offers a brief overview of TCR sequencing and how it has been applied in the field of therapeutic cancer vaccination. Additionally, we highlight common challenges encountered in the data analysis and present examples of how these can be overcome with state-of-the-art data analysis techniques.

Overview of a typical reverse vaccinology workflow

Reverse vaccinology

With the impending threats of antibiotic- resistant bacterial infections and future pandemics, implementing a fast and scalable vaccine development process is more urgent than ever. Reverse vaccinology is a computational vaccine-target identification method with stark benefits over traditional vaccine development. With a highly efficient pipeline, this bioinformatic technique allows for faster, safer, and cheaper vaccine development.

Find out more about reverse vaccinology in this white paper.

SARS-CoV-2 Omicron

Omicron, the latest SARS-CoV-2 variant of concern is characterized by a large number of mutations. Here we evaluate the effect of these mutations on T-cell immunity by applying a T-cell receptor (TCR)/epitope interaction model.

Graph showing the predictions made for TCR/epitope binding of the SARS-CoV-2 Omicron variant.

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