The leading software solution for T-cell receptor specificity annotations
Find and track the T cells that matter
Accelerate the development of your therapeutics and diagnostics by truly understanding T-cell responses. ImmuneWatch’s extensive database and software can annotate the epitope specificity of T-cell receptor (TCR) sequences, turning TCR repertoires into clinically actionable data.
ImmuneWatch DETECT
Extract therapy-, vaccine- or pathogen-specific TCRs from TCR repertoires to fully understand T-cell responses. Run ImmuneWatch’s machine learning platform on your own infrastructure or work with us to get the insights you need.
ImmuneWatch DESIGN
Find the right T cell epitopes and antigens for your vaccine with ImmuneWatch’s reverse vaccinology pipeline. Start from a protein or genome and get a ranked list of immunogenic epitopes or antigens.
How our technology works
TCR sequencing
TCR sequencing offers you an unprecedented deep insight in the composition of the T-cell receptor repertoire of a patient and its dynamics in response to a T-cell therapeutic or vaccine.
TCR sequencing can be performed on PBMCs, stimulated cells or tissue samples. ImmuneWatch’s technology is compatible with single cell or -bulk sequencing approaches.
Annotate the epitope specificity of TCRs
A bottle-neck in the analysis of TCR repertoires is the annotation of the epitope-specificity of TCRs. Based on > 7 years of research, ImmuneWatch has developed an extensive TCR-epitope database and annotation software that can link TCRs to their cognate epitope sequences. Find your therapy-, vaccine- or pathogen-specific TCRs in less than 2 minutes.
Immunoinformatic pipelines
ImmuneWatch is dedicated to offer a complete solution, from sequencing to immunoinformatics analysis. As experts in immunology and bioinformatics ImmuneWatch is able to provide a complete immunoinformatic pipeline from FASTQ to interactive reports.
Reverse vaccinology pipeline
Predict what parts of a pathogen will be most effective in a vaccine. ImmuneWatch’s unique algorithms provide not only insights in epitope presentation, but also into the prevalence of T cells that can potentially bind the peptide-MHC complexes (patent pending).
Advanced TCR sequencing and repertoire analysis helped us annotate these T cells and identify their specificity. This was not possible a few years ago.
ImmuneWatch assisted us in analysing reactive T-cells through TCR sequencing and data anaysis in an oncology setting. Together, we identified potential TCR candidates for further in vitro validation. This collaboration provided us with insights into T-cell reactivity and the immune profile of our stimulation experiments, advancing our understanding and guiding future research.
I used DETECT to screen TCRs in melanoma TIL data with scRNA-seq — looking for TAA-specific T cells, and I could identify my population of interest. It was super easy to use and very fast."
Going from a TCR sequence to its putative target is not an easy task. We found relief switching to ImmuneWatch DETECT. Now we can just say; here's an award-winning algorithm that people rely, trust, and this is what we are using.
The DESIGN analysis performed by ImmuneWatch is very informative and useful for making decisions on our different candidate antigens. Thank you for this nice work!
Some of our latest insights
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Find the epitope-specificity of your TCRs today
