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The future of cellular immune monitoring for vaccines is here!

Next-generation sequencing in immunology is here to stay

Next-Generation Sequencing (NGS) has caused many scientific disciplines to move from laborious cell experiments to high-throughput sequencing. Examples from this shift can be found in the genomics or microbiome research fields. Fortunately, this revolution has also made it into the field of immunology. Multiple single-cell or bulk-based sequencing approaches have been developed in the recent years.

A laboratory robot that prepares samples to peform DNA-sequencing, such as TCR repertoire sequencing, which can be useful for immune monitoring of vaccines
Next-generation sequencing is revolutionising immune monitoring in vaccinology
Want to learn more about how sequencing is revolutionising immune monitoring? We advise the following excellent papers as good primers into the subject:

T cell receptor repertoire sequencing in vaccinology

Each T-cell receptor in a T-cell receptor repertoire can recognise one or multiple pathogens.

There are plenty of methods to measure vaccine immunity. T cell receptor repertoire (TCR) sequencing is a promising technology that is rising in popularity and can be used to perform ex vivo in-depth cellular profiling of vaccine responses. Several advantages of using TCR sequencing instead of traditional methods include:

Here is our selection of papers that apply TCR sequencing in the context of immune monitoring for vaccines

Bioinformatic analysis of TCR repertoires in vaccinology

One result of switching to a high-throughput technology is that a large amount of data is generated. While this will give you the opportunity gain deeper insights into your vaccine-based immune response, it will also often increase the need for data analysis solutions and experts. Luckily at ImmuneWatch we have the expertise in house to take that pain away. Having both experts in immunology and bioinformatics on board, makes us the right partner for your vaccine immune monitoring project.

A network of data points connected, representing large scale data analysis
ImmuneWatch is your partner for the data analysis of your immune monitoring project

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There are plenty of methods to measure vaccine immunity. T cell receptor repertoire (TCR) sequencing is a promising technology that is rising in popularity and can be used to perform ex vivo in-depth cellular profiling of vaccine responses. Several advantages of using TCR sequencing instead of traditional methods include: